Once-daily INCRUSE is a prescription medicine used long term to treat chronic obstructive pulmonary disease (COPD), including chronic bronchitis, emphysema, or both, for better breathing and fewer flare-ups. INCRUSE is not used to relieve sudden breathing problems and won't replace a rescue inhaler.

WHAT IS COPD?

COPD is a condition that makes it hard to breathe. When you breathe, air travels through tubes in your lungs, also called airways, to millions of tiny air sacs. In a healthy lung, air easily moves in through the airways and fills the air sacs, and then is quickly released back out. For someone with COPD, it’s much tougher for air to move through the airways and into the air sacs and back out. A doctor may be able to diagnose COPD through a test called spirometry, which measures how much air you can breathe into your lungs and how quickly you can release it. Other tests or chest x-rays may help your doctor with diagnosing COPD. These breathing difficulties tend to worsen over time.

Millions of Americans are affected by COPD

Approximately 15 million adults in the US are diagnosed with COPD. It is estimated that millions more
have it and don't even know it.

There are several potential causes of COPD

Cigarette smoking is the most common cause of COPD. Most people who have COPD smoke or used to smoke. It's possible to have COPD even if you have never smoked. Secondhand cigarette smoke can also be a cause of COPD. There are several other potential causes of COPD, including:

Dust
Chemical
fumes at
work and
at home
Outdoor air
pollution
Indoor air quality
Respiratory
infections
Genetic
factors

How does COPD disrupt airflow?

COPD disrupts the airflow in and out of your lungs and reduces your lung function. Some of the reasons are:

  • Airways and air sacs lose elasticity.
  • The walls separating the air sacs become permanently damaged.
  • The walls of the airways become thick and inflamed.
  • The airways make more mucus than usual, which can clog them.

There are different types of COPD

COPD can include emphysema, chronic bronchitis, or both. Either emphysema or chronic bronchitis may reduce lung function, resulting in COPD symptoms that can make it difficult to breathe.

Emphysema

is a disease that damages the air sacs and may damage the small airways in the lungs. This significantly reduces your ability to expel the normal amount of air from the lungs. This causes shortness of breath and prevents the lungs from delivering oxygen into the blood.

Chronic bronchitis

involves increased cough and mucus production caused by inflammation of the airways. Bronchitis is considered chronic (or long term) if you cough and produce excess mucus most days for several months during 2 years in a row.

Learn what the symptoms of COPD are
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IMPORTANT SAFETY INFORMATION FOR INCRUSE

  • Do not use INCRUSE to relieve sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms.
  • Do not use INCRUSE if you have a severe allergy to milk proteins or any of the ingredients in INCRUSE. Ask your healthcare provider if you are not sure.
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IMPORTANT SAFETY
INFORMATION FOR INCRUSE

  • Do not use INCRUSE to relieve sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms.
  • Do not use INCRUSE if you have a severe allergy to milk proteins or any of the ingredients in INCRUSE. Ask your healthcare provider if you are not sure.
  • Do not use INCRUSE more often than prescribed.
  • Do not take INCRUSE with other medicines that contain an anticholinergic for any reason. Tell your healthcare provider about all the medicines you take and about all of your medical conditions. Especially tell your healthcare provider if you take anticholinergics including tiotropium, ipratropium, aclidinium, or atropine.
  • Get emergency medical care if your breathing problems worsen quickly or if you use your rescue inhaler but it does not relieve your breathing problems.
  • INCRUSE can cause serious side effects, including:
    • sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop taking INCRUSE and call your healthcare provider right away.
    • serious allergic reactions (anaphylaxis). Stop taking INCRUSE and call your healthcare provider or go to the nearest emergency room right away if you get any of the following symptoms of a serious allergic reaction: rash; hives; severe itching; swelling of your face, lips, mouth, or tongue; breathing problems.
    • new or worsening eye problems including acute narrow-angle glaucoma. You should have regular eye exams while using INCRUSE ELLIPTA. Acute narrow-angle glaucoma can cause permanent loss of vision if not treated. Symptoms of acute narrow-angle glaucoma may include: eye pain or discomfort; nausea or vomiting; blurred vision; seeing halos or bright colors around lights; red eyes. If you have these symptoms, call your healthcare provider right away before taking another dose.
    • urinary retention. People who take INCRUSE may develop new or worse urinary retention. Symptoms of urinary retention may include: difficulty urinating; painful urination; urinating frequently; urination in a weak stream or drips. If you have these symptoms of urinary retention, stop taking INCRUSE, and call your healthcare provider right away before taking another dose.
  • Common side effects of INCRUSE include upper respiratory tract infection, stuffy or runny nose, cough, mouth and throat pain, joint pain, change in taste, muscle pain, tooth pain, stomach pain, bruising or dark areas of skin, and fast or irregular heartbeat.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch,
or call 1-800-FDA-1088.