Once-daily INCRUSE is a prescription medicine used long term to treat chronic obstructive pulmonary disease (COPD), including chronic bronchitis, emphysema, or both, for better breathing and fewer flare-ups. INCRUSE is not used to relieve sudden breathing problems and won't replace a rescue inhaler.

There are a variety of treatment options for COPD, including lifestyle changes, therapies, and medications. Your doctor may recommend a combination of these approaches. If your COPD treatment includes specific medicines, the two most common types are rescue inhalers and maintenance treatments.

"RESCUE INHALER" AND "MAINTENANCE TREATMENT"–– WHAT DO THEY MEAN?

RESCUE INHALERS

  • Short-acting COPD medicines that work quickly in case of sudden breathing problems
  • They’re sometimes referred to as “quick relief” medications
  • They relax airway muscles within minutes and are generally effective for about 4 to 6 hours

MAINTENANCE TREATMENT

  • Long-acting medicines taken daily to help prevent symptoms from occurring
  • These treatments can include inhalers, oral medicines, and injections
  • Maintenance inhalers can include 1 (monotherapy), 2 (dual therapy), or 3 (triple therapy) COPD medicines delivered in 1 or more inhalers

TREAT COPD WITH LONG-ACTING MEDICINES

Long-acting medicines are taken daily to help prevent symptoms and flare-ups from occurring. Inhaled maintenance treatments may include one or more of the following long-acting medicines: LABA, LAMA, and ICS. These maintenance medicines may be combined in 1 or more inhalers.

TYPES OF MAINTENANCE TREATMENTS:

BRONCHODILATOR(S)

LAMA

LAMAs are medicines that keep the airways open by blocking the tightening of smooth muscle around your airways. INCRUSE is a LAMA.

LAMA/LABA

LAMAs and LABAs work together to open airways by relaxing muscles around the airways in your lungs. They keep them open by blocking the tightening of the airways’ smooth muscle.

ANTI-INFLAMMATORY AND BRONCHODILATOR(S)

ICS/LABA

These 2 medicines work together to improve breathing. ICSs reduce inflammation and swelling in your lungs, LABAs open airways by relaxing the smooth muscles in the airways in your lungs.

LAMA/LABA/ICS (triple therapy)

These 3 medicines combine to open airways, keep them open, and reduce inflammation. When 3 daily maintenance treatments are combined within 1 or 2 inhalers, this is called a “triple therapy.”

LAMA = long-acting muscarinic antagonist; LABA = long-acting beta2-adrenergic agonist; ICS = inhaled corticosteroid

Patients who take daily COPD maintenance medications but who still need better breathing could be prescribed triple therapy for their COPD. Talk to your doctor to see if a triple therapy option could be right for you.

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IMPORTANT SAFETY INFORMATION FOR INCRUSE

  • Do not use INCRUSE to relieve sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms.
  • Do not use INCRUSE if you have a severe allergy to milk proteins or any of the ingredients in INCRUSE. Ask your healthcare provider if you are not sure.
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IMPORTANT SAFETY
INFORMATION FOR INCRUSE

  • Do not use INCRUSE to relieve sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms.
  • Do not use INCRUSE if you have a severe allergy to milk proteins or any of the ingredients in INCRUSE. Ask your healthcare provider if you are not sure.
  • Do not use INCRUSE more often than prescribed.
  • Do not take INCRUSE with other medicines that contain an anticholinergic for any reason. Tell your healthcare provider about all the medicines you take and about all of your medical conditions. Especially tell your healthcare provider if you take anticholinergics including tiotropium, ipratropium, aclidinium, or atropine.
  • Get emergency medical care if your breathing problems worsen quickly or if you use your rescue inhaler but it does not relieve your breathing problems.
  • INCRUSE can cause serious side effects, including:
    • sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop taking INCRUSE and call your healthcare provider right away.
    • serious allergic reactions (anaphylaxis). Stop taking INCRUSE and call your healthcare provider or go to the nearest emergency room right away if you get any of the following symptoms of a serious allergic reaction: rash; hives; severe itching; swelling of your face, lips, mouth, or tongue; breathing problems.
    • new or worsening eye problems including acute narrow-angle glaucoma. You should have regular eye exams while using INCRUSE ELLIPTA. Acute narrow-angle glaucoma can cause permanent loss of vision if not treated. Symptoms of acute narrow-angle glaucoma may include: eye pain or discomfort; nausea or vomiting; blurred vision; seeing halos or bright colors around lights; red eyes. If you have these symptoms, call your healthcare provider right away before taking another dose.
    • urinary retention. People who take INCRUSE may develop new or worse urinary retention. Symptoms of urinary retention may include: difficulty urinating; painful urination; urinating frequently; urination in a weak stream or drips. If you have these symptoms of urinary retention, stop taking INCRUSE, and call your healthcare provider right away before taking another dose.
  • Common side effects of INCRUSE include upper respiratory tract infection, stuffy or runny nose, cough, mouth and throat pain, joint pain, change in taste, muscle pain, tooth pain, stomach pain, bruising or dark areas of skin, and fast or irregular heartbeat.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch,
or call 1-800-FDA-1088.